| http://purl.uniprot.org/citations/12939402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12939402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12939402 | http://www.w3.org/2000/01/rdf-schema#comment | "The DF3/MUC1 transmembrane oncoprotein is aberrantly overexpressed in most human breast carcinomas and interacts with the Wnt effector gamma-catenin. Here, we demonstrate that MUC1 associates constitutively with ErbB2 in human breast cancer cells and that treatment with heregulin/neuregulin-1 (HRG) increases the formation of MUC1-ErbB2 complexes. The importance of the MUC1-ErbB2 interaction is supported by the demonstration that HRG induces binding of MUC1 and gamma-catenin and targeting of the MUC1-gamma-catenin complex to the nucleolus. Significantly, nucleolar localization of gamma-catenin in response to HRG is dependent on MUC1 expression. Moreover, mutation of a RRK motif in the MUC1 cytoplasmic domain abrogates HRG-induced nucleolar localization of MUC1 and gamma-catenin. In concert with these results, we show nucleolar localization of MUC1 and gamma-catenin in human breast carcinomas but not in normal mammary ductal epithelium. These findings demonstrate that MUC1 functions in cross talk between ErbB2 and Wnt pathways by acting as a shuttle for HRG-induced nucleolar targeting of gamma-catenin."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Kharbanda S."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Kharbanda S."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Loda M."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Loda M."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Yu W.-H."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/author | "Yu W.-H."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/name | "Mol. Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/name | "Mol. Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/pages | "765-775"xsd:string |
| http://purl.uniprot.org/citations/12939402 | http://purl.uniprot.org/core/pages | "765-775"xsd:string |