| http://purl.uniprot.org/citations/12941272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12941272 | http://www.w3.org/2000/01/rdf-schema#comment | "E type cyclins (E1 and E2) are believed to drive cell entry into the S phase. It is widely assumed that the two E type cyclins are critically required for proliferation of all cell types. Here, we demonstrate that E type cyclins are largely dispensable for mouse development. However, endoreplication of trophoblast giant cells and megakaryocytes is severely impaired in the absence of cyclin E. Cyclin E-deficient cells proliferate actively under conditions of continuous cell cycling but are unable to reenter the cell cycle from the quiescent G(0) state. Molecular analyses revealed that cells lacking cyclin E fail to normally incorporate MCM proteins into DNA replication origins during G(0)-->S progression. We also found that cyclin E-deficient cells are relatively resistant to oncogenic transformation. These findings define a molecular function for E type cyclins in cell cycle reentry and reveal a differential requirement for cyclin E in normal versus oncogenic proliferation."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00645-7"xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Geng Y."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Yu Q."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Bronson R.T."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Gardner H."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Schneider J.E."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Das M."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Sicinski P."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Rideout W.M."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/author | "Sicinska E."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/pages | "431-443"xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/title | "Cyclin E ablation in the mouse."xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/12941272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12941272 |
| http://purl.uniprot.org/citations/12941272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12941272 |
| http://purl.uniprot.org/uniprot/Q61457#attribution-9D489499AABEA2C78938028A5860EAB3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12941272 |
| http://purl.uniprot.org/uniprot/Q9Z238#attribution-9D489499AABEA2C78938028A5860EAB3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12941272 |
| http://purl.uniprot.org/uniprot/P97310#attribution-E394BEE4EE1A7A509B1622194BC51497 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12941272 |
| http://purl.uniprot.org/uniprot/Q60862#attribution-E394BEE4EE1A7A509B1622194BC51497 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12941272 |
| http://purl.uniprot.org/uniprot/#_A0A087WPP9-mappedCitation-12941272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12941272 |