| http://purl.uniprot.org/citations/12941698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12941698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12941698 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine signaling to the nucleus through cell surface transmembrane receptor serine/threonine kinases and cytoplasmic effectors, including Smad proteins. We describe a novel modulator of this pathway, TLP (TRAP-1-like protein), which is 25% identical to the previously described Smad4 chaperone, TRAP-1, and shows identical expression patterns in human tissues. Endogenous TLP associates with both active and kinase-deficient TGF-beta and activin type II receptors, but interacts with the common-mediator Smad4 only in the presence of TGF-beta/activin signaling. Overexpression of TLP represses the ability of TGF-beta to induce transcription from SBE-Luc, a Smad3/4-specific reporter, while it potentiates transcription from ARE-Luc, a Smad2/4-specific reporter. Consistent with this, TLP inhibits the formation of Smad3/4 complexes in the absence of effects on phosphorylation of Smad3, while it affects neither Smad2 phosphorylation nor hetero-oligomerization. We propose that TLP might regulate the balance of Smad2 and Smad3 signaling by localizing Smad4 intracellularly, thus contributing to cellular specificity of TGF-beta transcriptional responses in both normal and pathophysiology."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg428"xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg428"xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Reiss M."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Reiss M."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Roberts A.B."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Roberts A.B."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "McNally J.G."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "McNally J.G."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Karpova T.S."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Karpova T.S."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Felici A."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Felici A."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Giam L.R."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Giam L.R."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Parks W.T."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Parks W.T."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Wurthner J.U."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/author | "Wurthner J.U."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12941698 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |