| http://purl.uniprot.org/citations/12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12942088 | http://www.w3.org/2000/01/rdf-schema#comment | "Axon growth during neural development is highly dependent on both cytoskeletal re-organization and polarized membrane trafficking. Previously, we demonstrated that collapsin response mediator protein-2 (CRMP-2) is critical for specifying axon/dendrite fate and axon growth in cultured hippocampal neurons, possibly by interacting with tubulin heterodimers and promoting microtubule assembly. Here, we identify Numb as a CRMP-2-interacting protein. Numb has been shown to interact with alpha-adaptin and to be involved in endocytosis. We found that Numb was associated with L1, a neuronal cell adhesion molecule that is endocytosed and recycled at the growth cone, where CRMP-2 and Numb were colocalized. Furthermore, expression of dominant-negative CRMP-2 mutants or knockdown of CRMP-2 message with small-interfering (si) RNA inhibited endocytosis of L1 at axonal growth cones and suppressed axon growth. These results suggest that in addition to regulating microtubule assembly, CRMP-2 is involved in polarized Numb-mediated endocytosis of proteins such as L1."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1039"xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/author | "Matsuura Y."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/author | "Kaibuchi K."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/author | "Nishimura T."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/author | "Fukata Y."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/author | "Kamiguchi H."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/pages | "819-826"xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/title | "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth."xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/12942088 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12942088 |
| http://purl.uniprot.org/citations/12942088 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12942088 |
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| http://purl.uniprot.org/uniprot/#_A6K6N4-mappedCitation-12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12942088 |
| http://purl.uniprot.org/uniprot/#_P32004-mappedCitation-12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12942088 |
| http://purl.uniprot.org/uniprot/#_P49757-mappedCitation-12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12942088 |
| http://purl.uniprot.org/uniprot/#_Q16555-mappedCitation-12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12942088 |
| http://purl.uniprot.org/uniprot/#_O94973-mappedCitation-12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12942088 |
| http://purl.uniprot.org/uniprot/#_O95782-mappedCitation-12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12942088 |
| http://purl.uniprot.org/uniprot/#_P47942-mappedCitation-12942088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12942088 |