| http://purl.uniprot.org/citations/12944485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12944485 | http://www.w3.org/2000/01/rdf-schema#comment | "Megakaryoblastic leukemia 1 (MKL1) is a myocardin-related transcription factor that we found strongly activated serum response element (SRE)-dependent reporter genes through its direct binding to serum response factor (SRF). The c-fos SRE is regulated by mitogen-activated protein kinase phosphorylation of ternary complex factor (TCF) but is also regulated by a RhoA-dependent pathway. The mechanism of this pathway is unclear. Since MKL1 (also known as MAL, BSAC, and MRTF-A) is broadly expressed, we assessed its role in serum induction of c-fos and other SRE-regulated genes with a dominant negative MKL1 mutant (DN-MKL1) and RNA interference (RNAi). We found that DN-MKL1 and RNAi specifically blocked SRE-dependent reporter gene activation by serum and RhoA. Complete inhibition by RNAi required the additional inhibition of the related factor MKL2 (MRTF-B), showing the redundancy of these factors. DN-MKL1 reduced the late stage of serum induction of endogenous c-fos expression, suggesting that the TCF- and RhoA-dependent pathways contribute to temporally distinct phases of c-fos expression. Furthermore, serum induction of two TCF-independent SRE target genes, SRF and vinculin, was nearly completely blocked by DN-MKL1. Finally, the RBM15-MKL1 fusion protein formed by the t(1;22) translocation of acute megakaryoblastic leukemia had a markedly increased ability to activate SRE reporter genes, suggesting that its activation of SRF target genes may contribute to leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.18.6597-6608.2003"xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/author | "Ma Z."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/author | "Morris S.W."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/author | "Burgess R.C."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/author | "Cen B."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/author | "Prywes R."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/author | "Hitzler J.K."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/author | "Selvaraj A."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/pages | "6597-6608"xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/title | "Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes."xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12944485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12944485 |
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