| http://purl.uniprot.org/citations/12944902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12944902 | http://www.w3.org/2000/01/rdf-schema#comment | "Cross-talk between signaling pathways plays an important role in regulation of cell growth, differentiation, survival, and death. Here, we show that Akt regulates the Elk-1 transcription factor, independent of its negative regulation of Raf kinases. Using a constitutively active Mek1 to bypass the regulation of Raf by Akt, we find that the Elk-1 and Sap1a proteins are dramatically decreased in the presence of activated Akt. Akt catalytic activity is required. Also, Mek-dependent activation of a TCF (Elk-1/Sap-1a)-dependent c-fos reporter is decreased by activated Akt. Neither the level of Elk-1 mRNA nor the stability of the Elk-1 protein is altered by activated Akt. Instead, the rate of incorporation of labeled methionine into Elk-1 protein is decreased in the presence of Akt. In addition, the level of the Elk-1 protein but not GFP is significantly decreased in the presence of activated Akt, when GFP is expressed from an IRES element in a bicistronic message with Elk-1. We conclude that Akt negatively regulates translation of the Elk-1 mRNA. A coding region determinant that maps within the first 279 nts of the Elk-1 message is necessary and sufficient for Akt-mediated regulation of Elk-1."xsd:string |
| http://purl.uniprot.org/citations/12944902 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206496"xsd:string |
| http://purl.uniprot.org/citations/12944902 | http://purl.uniprot.org/core/author | "Figueroa C."xsd:string |
| http://purl.uniprot.org/citations/12944902 | http://purl.uniprot.org/core/author | "Vojtek A.B."xsd:string |
| http://purl.uniprot.org/citations/12944902 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12944902 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12944902 | http://purl.uniprot.org/core/pages | "5554-5561"xsd:string |
| http://purl.uniprot.org/citations/12944902 | http://purl.uniprot.org/core/title | "Akt negatively regulates translation of the ternary complex factor Elk-1."xsd:string |
| http://purl.uniprot.org/citations/12944902 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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