Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12948297http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Type 1 diabetes mellitus (DM1) is frequently accompanied by thyroid autoimmunity (TAI). The aims of the present study were to estimate the prevalence of TAI and to determine the contribution of HLA-DQA1 and -DQB1 polymorphisms to TAI susceptibility among children with DM1. PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). HLA-DQA1 and -DQB1 were genotyped using PCR-SSP.

Results

Repeated positivity of anti-TPO and/or anti-Tg was found in 45/285 children with DM1 (15.8%). The prevalence was significantly higher in girls than in boys (26.7% vs 6.7%; p<10(-5)). The HLA-DQB1*0302 allele conferred susceptibility to TAI in children with DM1 (OR 2.7, 95% CI 1.1-6.4), while the DQB1*05 alleles acted protectively (OR 0.2, CI 95% 0.08-0.7).

Conclusions

HLA-DQ polymorphisms significantly modify the risk of TAI in children with DM1."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.org/dc/terms/identifier"doi:10.1515/jpem.2003.16.6.851"xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Cinek O."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Sumnik Z."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Drevinek P."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Kolouskova S."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Snajderova M."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Vavrinec J."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Pechova M."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/author"Sedlakova P."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/name"J Pediatr Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/pages"851-858"xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/title"HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus."xsd:string
http://purl.uniprot.org/citations/12948297http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/12948297http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12948297
http://purl.uniprot.org/citations/12948297http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12948297
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12948297
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12948297
http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12948297
http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12948297
http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12948297
http://purl.uniprot.org/uniprot/#_A0A0A7CAC7-mappedCitation-12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12948297
http://purl.uniprot.org/uniprot/#_A0A0A7CAE0-mappedCitation-12948297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12948297
▶