| http://purl.uniprot.org/citations/12951053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12951053 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse embryonic stem (ES) cells are clonal cell lines derived from the inner cell mass of developing blastocysts and have multi-lineage differentiation ability. We previously reported that ES cells can be made to differentiate into hepatocytes possessing high metabolic activities by transfection of hepatocyte nuclear factor-3beta (HNF-3beta). In the present study, we investigated the expression of hepatobiliary organic anion transporters and bilirubin uridine diphosphate glucuronosyltransferase (ugt1a1) in undifferentiated and differentiating HNF-3beta-transfected ES (HNF-3beta-ES) cells. The expression of organic anion transporting polypeptide 1 (oatp1), multidrug resistance-associated protein 1 (mrp1), mrp2, mrp3, and ugt1a1 was not seen in the undifferentiated HNF-3beta-ES cells by RT-PCR, whereas all were expressed in differentiating HNF-3beta-ES cells. Protein expression for oatp1, mrp1, mrp2, mrp3, and ugt1a1 was also observed in the differentiating HNF-3beta-ES cells by Western blotting. An immunofluorescence examination revealed that oatp1 was co-located with desmoplakin, a marker for the basolateral (sinusoidal) membrane, and mrp2 was co-localized with CD26, a marker for the apical (canalicular) membrane, though they were both expressed throughout most of the cell membranes."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.07.005"xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Yoshikawa M."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Adachi Y."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Fukui H."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Ishizaka S."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Kaito M."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Shiroi A."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/author | "Yamao J."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/pages | "324-330"xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/title | "Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://purl.uniprot.org/core/volume | "309"xsd:string |
| http://purl.uniprot.org/citations/12951053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12951053 |
| http://purl.uniprot.org/citations/12951053 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12951053 |
| http://purl.uniprot.org/uniprot/E9Q557#attribution-CC0D391C1D34CE116AC294FF2199A52A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12951053 |
| http://purl.uniprot.org/uniprot/B2RX12#attribution-CC0D391C1D34CE116AC294FF2199A52A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12951053 |
| http://purl.uniprot.org/uniprot/O35379#attribution-CC0D391C1D34CE116AC294FF2199A52A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12951053 |
| http://purl.uniprot.org/uniprot/Q8VI47#attribution-CC0D391C1D34CE116AC294FF2199A52A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12951053 |
| http://purl.uniprot.org/uniprot/Q9QXZ6#attribution-CC0D391C1D34CE116AC294FF2199A52A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12951053 |