| http://purl.uniprot.org/citations/12952069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12952069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12952069 | http://www.w3.org/2000/01/rdf-schema#comment | "Dictyostelium myosin II is a conventional, two-headed myosin that consists of two copies each of a myosin heavy chain (MHC), an essential light chain (ELC) and a regulatory light chain (RLC). The MHC is comprised of an amino-terminal motor domain, a neck region that binds the RLC and ELC and a carboxyl-terminal alpha-helical coiled-coil tail. Electrostatic interactions between the tail domains mediate the self-assembly of myosin II into bipolar filaments that are capable of interacting with actin filaments to generate a contractile force. In this review we discuss the regulation of Dictyostelium myosin II by a myosin light chain kinase (MLCK-A) that phosphorylates the RLC and increases motor activity and by MHC kinases (MHCKs) that phosphorylate the tail and prevent filament assembly. Dictyostelium may express as many as four MHCKs (MHCK A-D) consisting of an atypical alpha-kinase catalytic domain and a carboxyl-terminal WD repeat domain that targets myosin II filaments. A previously reported MHCK, termed MHC-PKC, now seems more likely to be a diacylglycerol kinase (DgkA). The relationship of the MHCKs to the larger family of alpha-kinases is discussed and key features of the structure of the alpha-kinase catalytic domain are reviewed. Potential upstream regulators of myosin II are described, including DgkA, cGMP, cAMP and PAKa, a target for Rac GTPases. Recent results point to a complex network of signaling pathways responsible for controling the activity and localization of myosin II in the cell."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.org/dc/terms/identifier | "doi:10.1023/a:1024467426244"xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.org/dc/terms/identifier | "doi:10.1023/a:1024467426244"xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Smith J.L."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Smith J.L."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Betapudi V."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Betapudi V."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Egelhoff T.T."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Egelhoff T.T."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Cote G.P."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "Cote G.P."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "De la Roche M.A."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/author | "De la Roche M.A."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/name | "J. Muscle Res. Cell Motil."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/name | "J. Muscle Res. Cell Motil."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/pages | "703-718"xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/pages | "703-718"xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/title | "Signaling pathways regulating Dictyostelium myosin II."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/title | "Signaling pathways regulating Dictyostelium myosin II."xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12952069 | http://purl.uniprot.org/core/volume | "23"xsd:string |