| http://purl.uniprot.org/citations/12952940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12952940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12952940 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing beta-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of beta-catenin. This pathway is Siah2 and APC dependent, but GSK-3 and beta-TrCP independent. Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200303158"xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200303158"xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Choi H."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Choi H."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Garrett-Beal L."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Garrett-Beal L."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Carolan P.J."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Carolan P.J."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Topol L."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/author | "Topol L."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/pages | "899-908"xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/pages | "899-908"xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/title | "Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation."xsd:string |
| http://purl.uniprot.org/citations/12952940 | http://purl.uniprot.org/core/title | "Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation."xsd:string |