| http://purl.uniprot.org/citations/12956878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12956878 | http://www.w3.org/2000/01/rdf-schema#comment | "In unrelated stem-cell transplantation, the value of matching at the HLA-A, -B and -DR loci between donor and recipient is well documented. The effect of HLA-C, DPB1 and DPA1 mismatches on transplantation outcome is unclear. In this study, 104 donor recipient-pairs, transplanted at Huddinge University Hospital between 1988 and 1999, were retrospectively HLA class I- and class II-typed by PCR-SSP. The samples were typed for HLA-A, -B and -C and HLA-DRB1, -DRB3, -DRB4, -DRB5, -DQA1, -DQB1, -DPB1 and -DPA1 with allele level resolution. Isolated HLA-B allele level mismatches were associated with an increased incidence of acute graft versus host disease grades II-IV and grades III-IV. HLA-C-mismatched, but killer cell immunoglobulin-like receptor (KIR) ligand motif-matched stem-cell grafts were significantly associated with improved survival rates and relapse-free survival (RFS). In patients receiving HLA-DPA1-mismatched stem cell grafts, reduced survival and shorter RFS were seen. These patients also had an increased frequency of relapses (64%vs 26%). We conclude that genomic HLA class I- and class II-typing may improve the outcome after unrelated stem-cell transplantation. The awareness of HLA class I- and II-mismatches in a recipient-donor pair makes it possible to give appropriate pre- and post-transplantation treatment."xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1399-0039.2003.00089.x"xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/author | "Schaffer M."xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/author | "Olerup O."xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/author | "Remberger M."xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/author | "Ringden O."xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/author | "Aldener-Cannava A."xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/pages | "243-250"xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/title | "Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/12956878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12956878 |
| http://purl.uniprot.org/citations/12956878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12956878 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-12956878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12956878 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-12956878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12956878 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-12956878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12956878 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-12956878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12956878 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-12956878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12956878 |