| http://purl.uniprot.org/citations/12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12958214 | http://www.w3.org/2000/01/rdf-schema#comment | "SPA-1 is a principal Rap1 GTPase-activating protein in the hematopoietic progenitors and peripheral T cells, and SPA-1-deficient mice develop a spectrum of myeloproliferative stem cell disorders of late onset. In the present study, we show that SPA-1-deficient mice develop age-dependent T cell unresponsiveness preceding the myeloid disorders, whereas the T cell numbers remained unchanged. Progression of the T cell dysfunction was attributed to the age-dependent increase in CD44high T cell population that was unresponsive to T cell receptor stimulation. Younger SPA-1-deficient mice exhibited selectively impaired recall T cell responses against a T-dependent antigen with normal primary antibody response. These results suggested that the unresponsiveness of CD44high T cells was antigen-driven in vivo. T cells from younger SPA-1-/-mice showed much greater and more persisted Rap1 activation by anti-CD3 stimulation than control T cells. Furthermore, freshly isolated T cells from SPA-1-/-mice exhibited progressive accumulation of Rap1GTP as mice aged. T cells from aged SPA-1-/-mice with high amounts of Rap1GTP showed normal or even enhanced Ras activation with little extracellular signal-regulated kinase activation in response to anti-CD3 stimulation, indicating that excess Rap1GTP induced the uncoupling of Ras-mediated extracellular signal-regulated kinase activation. These results suggested that antigenic activation of naïve T cells in SPA-1-/-mice was followed by anergic rather than memory state due to the defective down-regulation of Rap1 activation, resulting in the age-dependent progression of overall T cell immunodeficiency."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1834525100"xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/author | "Masuda K."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/author | "Minato N."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/author | "Kawamoto H."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/author | "Uesugi K."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/author | "Ishida D."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/pages | "10919-10924"xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/title | "Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12958214 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12958214 |
| http://purl.uniprot.org/citations/12958214 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12958214 |
| http://purl.uniprot.org/uniprot/#_E9Q0Y4-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |
| http://purl.uniprot.org/uniprot/#_A0A494BAM3-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |
| http://purl.uniprot.org/uniprot/#_Q3U146-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |
| http://purl.uniprot.org/uniprot/#_P46062-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |
| http://purl.uniprot.org/uniprot/#_Q3UV58-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |
| http://purl.uniprot.org/uniprot/#_Q3V403-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |
| http://purl.uniprot.org/uniprot/#_Q3UE96-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |
| http://purl.uniprot.org/uniprot/#_Q7TMS2-mappedCitation-12958214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12958214 |