| http://purl.uniprot.org/citations/12958311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12958311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12958311 | http://www.w3.org/2000/01/rdf-schema#comment | "The androgen receptor (AR), a member of the nuclear hormone receptor superfamily, functions as a ligand-dependent transcription factor that regulates genes involved in cell proliferation and differentiation. Using a C-terminal region of the human AR in a yeast two-hybrid screen, we have identified RACK1 (receptor for activated C kinase-1) as an AR-interacting protein. In this report we found that RACK1, which was previously shown to be a protein kinase C (PKC)-anchoring protein that determines the localization of activated PKCbetaII isoform, facilitates ligand-independent AR nuclear translocation upon PKC activation by indolactam V. We also observed RACK1 to suppress ligand-dependent and -independent AR transactivation through PKC activation. In chromatin immunoprecipitation assays, we demonstrate a decrease in AR recruitment to the AR-responsive prostate-specific antigen (PSA) promoter following stimulation of PKC. Furthermore, prolonged exposure to indolactam V, a PKC activator, caused a reduction in PSA mRNA expression in prostate cancer LNCaP cells. Finally, we found PKC activation to have a repressive effect on AR and PSA protein expression in androgen-treated LNCaP cells. Our data suggest that RACK1 may function as a scaffold for the association and modification of AR by PKC enabling translocation of AR to the nucleus but rendering AR unable to activate transcription of its target genes."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306219200"xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306219200"xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Neal D.E."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Neal D.E."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Ozanne D.M."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Ozanne D.M."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Rigas A.C."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Rigas A.C."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Robson C.N."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/author | "Robson C.N."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/pages | "46087-46093"xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/pages | "46087-46093"xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/title | "The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/title | "The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12958311 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12958311 |
| http://purl.uniprot.org/citations/12958311 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12958311 |