| http://purl.uniprot.org/citations/12958362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12958362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12958362 | http://www.w3.org/2000/01/rdf-schema#comment | "The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10(-21) molar) sensitivity to free Cu+, which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn2+-sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1085950"xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1085950"xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Outten C.E."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Outten C.E."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Mondragon A."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Mondragon A."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "O'Halloran T.V."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "O'Halloran T.V."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Changela A."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Changela A."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Holschen J."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/author | "Holschen J."xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/pages | "1383-1387"xsd:string |
| http://purl.uniprot.org/citations/12958362 | http://purl.uniprot.org/core/pages | "1383-1387"xsd:string |