| http://purl.uniprot.org/citations/12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12960248 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagocytosis is a complex process engaging a concerted action of signal-transduction cascades that leads to ingestion, subsequent phagolysosome fusion, and oxidative activation. We have previously shown that in human neutrophils, C3bi-mediated phagocytosis elicits a significant oxidative response, suggesting that activation of the small GTPase Rac is involved in this process. This is contradictory to macrophages, where only Fc receptor for immunoglobulin G (FcgammaR)-mediated activation is Rac-dependent. The present study shows that engagement of the complement receptor 3 (CR3) and FcgammaR and CR3- and FcgammaR-mediated phagocytosis activates Rac, as well as Cdc42. Furthermore, following receptor-engagement of the CR3 or FcgammaRs, a downstream target of these small GTPases, p21-activated kinase, becomes phosphorylated, and Rac2 is translocated to the membrane fraction. Using the methyltransferase inhibitors N-acetyl-S-farnesyl-L-cysteine and N-acetyl-S-geranylgeranyl-L-cysteine, we found that the phagocytic uptake of bacteria was not Rac2- or Cdc42-dependent, whereas the oxidative activation was decreased. In conclusion, our results indicate that in neutrophils, Rac2 and Cdc42 are involved in FcR- and CR3-induced activation and for properly functioning signal transduction involved in the generation of oxygen radicals."xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.1102525"xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/author | "Forsberg M."xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/author | "Stendahl O."xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/author | "Druid P."xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/author | "Sarndahl E."xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/pages | "611-619"xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/title | "Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils."xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/12960248 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12960248 |
| http://purl.uniprot.org/citations/12960248 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12960248 |
| http://purl.uniprot.org/uniprot/#_B4E1U9-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_B1AH79-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_B1AH80-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_B4DMH5-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_B7ZAY4-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_P15153-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_P60953-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_Q9UJM0-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_Q9UJM1-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |
| http://purl.uniprot.org/uniprot/#_V9H0H7-mappedCitation-12960248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12960248 |