| http://purl.uniprot.org/citations/12963692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12963692 | http://www.w3.org/2000/01/rdf-schema#comment | "The control of many persistent viral infections by Ag-specific cytolytic CD8+ T cells requires a concurrent virus-specific CD4+ Th cell response. This reflects in part a requirement of activated effector CD8+ T cells for paracrine IL-2 production as a growth and survival factor. In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. Analysis of the fraction of memory CD8+ T cells that continue to express CD28 revealed these cells retain the ability to produce IL-2. Therefore, we examined if IL-2 production by CD28-CD8+ T cells could be restored by introduction of a constitutively expressed CD28 gene. Expression of CD28 in CD28- CD8+ CMV- and HIV-specific CD8+ T cells reconstituted the ability to produce IL-2, which could sustain an autocrine proliferative response after Ag recognition. These results suggest that the loss of CD28 expression during differentiation of memory/effector CD8+ T cells represents a decisive step in establishing regulation of responding CD8+ T cells, increasing the dependence on CD4+ Th for proliferation after target recognition, and has implications for the treatment of viral disease with adoptively transferred CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021288"xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/author | "Riddell S.R."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/author | "Blattman J.N."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/author | "Greenberg P.D."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/author | "Akatsuka Y."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/author | "Topp M.S."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/author | "Jensen M.C."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/pages | "947-955"xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/title | "Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production."xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/12963692 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12963692 |
| http://purl.uniprot.org/citations/12963692 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12963692 |
| http://purl.uniprot.org/uniprot/#_B4E0L1-mappedCitation-12963692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12963692 |
| http://purl.uniprot.org/uniprot/#_P10747-mappedCitation-12963692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12963692 |
| http://purl.uniprot.org/uniprot/P10747 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12963692 |
| http://purl.uniprot.org/uniprot/B4E0L1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12963692 |