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http://purl.uniprot.org/citations/12969160http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12969160http://www.w3.org/2000/01/rdf-schema#comment"

Background

Nephrotoxic glomerulonephritis is induced by the administration of antibody against the glomerular basement membrane (GBM). We demonstrated previously that Fc receptors for immunoglobulin G (IgG) (FcgammaR) play crucial roles in the induction of accelerated nephrotoxic glomerulonephritis by using FcRgamma-deficient (-/-) mice. Since FcRgamma-/-mice lack the cell surface expression of two activating FcgammaRs, FcgammaRI and FcgammaRIII. The present study aims to identify the FcgammaR responsible for the induction of nephrotoxic glomerulonephritis.

Methods

Accelerated anti-GBM glomerulonephritis was induced in FcgammaRI-/-, FcgammaRIII-/-, and FcRgamma-/-mice by preimmunization with rabbit IgG followed by inoculation of rabbit anti-GBM antibody. Histologic analysis and immunostaining of renal sections were performed.

Results

FcgammaRI-/-mice as well as wild-type mice showed severe glomerulonephritis with hypernitremia by the administration of anti-GBM antibody. In contrast, FcgammaRIII-/- mice showed much milder renal involvement, similar to FcRgamma-/-mice. Histologically, FcgammaRI-/-mice showed intracapillary proliferation, glomerular thrombosis, and crescent formation, whereas FcgammaRIII-/-mice showed only glomerular hypercellular changes. The depositions of anti-GBM antibodies, autologous antibodies and complement C3 along the GBM were equally observed among all three FcR-/-mouse types by immunostaining.

Conclusions

Accelerated nephrotoxic glomerulonephritis is induced predominantly through FcgammaRIII but not FcgammaRI."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.org/dc/terms/identifier"doi:10.1046/j.1523-1755.2003.00203.x"xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Fujii T."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Ogawa M."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Saito T."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Yamasaki S."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Ueda S."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Taki S."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Hamano Y."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Saisho H."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Verbeek J.S."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/author"Akikusa B."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/name"Kidney Int"xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/pages"1406-1416"xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/title"Predominant role of FcgammaRIII in the induction of accelerated nephrotoxic glomerulonephritis."xsd:string
http://purl.uniprot.org/citations/12969160http://purl.uniprot.org/core/volume"64"xsd:string
http://purl.uniprot.org/citations/12969160http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12969160
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