| http://purl.uniprot.org/citations/12970338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12970338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12970338 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium (Ca2+) signaling-dependent systems, such as the epidermal differentiation process, must effectively respond to variations in Ca2+ concentration. Members of the Ca2+-binding proteins play a central function in the transduction of Ca2+ signals, exerting their roles through a Ca2+-dependent interaction with their target proteins, spatially and temporally. By performing a suppression subtractive hybridization screen we identified a novel mouse gene, Scarf (skin calmodulin-related factor), which has homology to calmodulin (CaM)-like Ca2+-binding protein genes and is exclusively expressed in differentiating keratinocytes in the epidermis. The Scarf open reading frame encodes a 148-amino acid protein that contains four conserved EF-hand motifs (predicted to be Ca2+-binding domains) and has homology to mouse CaM, human CaM-like protein, hClp, and human CaM-like skin protein, hClsp. The functionality of Scarf EF-hand domains was assayed with a radioactive Ca2+-binding method. By Southern blot and computational genome sequence analysis, a highly related gene, Scarf2, was found 15 kb downstream of Scarf on mouse chromosome 13. The functional Scarf Ca2+-binding domains suggest a role in the regulation of epidermal differentiation through the control of Ca2+-mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M306561200"xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306561200"xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/author | "Hwang M."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/author | "Hwang M."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/author | "Morasso M.I."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/author | "Morasso M.I."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/pages | "47827-47833"xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/pages | "47827-47833"xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/title | "The novel murine Ca2+-binding protein, Scarf, is differentially expressed during epidermal differentiation."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/title | "The novel murine Ca2+-binding protein, Scarf, is differentially expressed during epidermal differentiation."xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12970338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12970338 |
| http://purl.uniprot.org/citations/12970338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12970338 |
| http://purl.uniprot.org/citations/12970338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12970338 |
| http://purl.uniprot.org/citations/12970338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12970338 |
| http://purl.uniprot.org/uniprot/Q6WEH7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12970338 |
| http://purl.uniprot.org/uniprot/Q6W3E0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12970338 |