| http://purl.uniprot.org/citations/12972182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12972182 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroid biosynthesis in ovary is enhanced by the orphan nuclear receptor, steroidogenic factor-1 (SF-1); however, we reported that liver receptor homolog-1 (LRH-1), a closely related receptor to SF-1, is also expressed in mouse ovary. To further investigate the role of LRH-1 in mouse ovary, we used in situ hybridization to identify the cell types that express LRH-1 versus SF-1, and carried out functional studies to determine the role of LRH-1 in the regulation of the human (h) ovary-specific CYP19 promoter. LRH-1 expression was found to be abundant and highly restricted to cells involved in estrogen biosynthesis-granulosa cells during the estrous cycle, and in corpora lutea (CL) of pregnancy. In contrast, SF-1 was expressed most highly in C(19)-steroid-producing theca cells and interstitium, and at low levels in granulosa and luteal cells. Transfection studies using granulosa cells demonstrated that LRH-1 is a potent regulator of both basal and forskolin-induced transcription of the ovary-specific hCYP19 promoter. This activity was dependent upon two nuclear receptor half-sites within the proximal hCYP19 promoter. Based on these findings, we propose that LRH-1 plays an important role as a competence factor in regulating aromatase, and thus estrogen biosynthesis, in ovary."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0303-7207(03)00257-0"xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/author | "Mangelsdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/author | "Repa J.J."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/author | "Shelton J.M."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/author | "Hinshelwood M.M."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/author | "Mendelson C.R."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/pages | "39-45"xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/title | "Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function."xsd:string |
| http://purl.uniprot.org/citations/12972182 | http://purl.uniprot.org/core/volume | "207"xsd:string |
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