| http://purl.uniprot.org/citations/12972592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12972592 | http://www.w3.org/2000/01/rdf-schema#comment | "Liver receptor homolog 1 (LRH-1) and pancreatic-duodenal homeobox 1 (PDX-1) are coexpressed in the pancreas during mouse embryonic development. Analysis of the regulatory region of the human LRH-1 gene demonstrated the presence of three functional binding sites for PDX-1. Electrophoretic mobility shift assays and chromatin immunoprecipitation analysis showed that PDX-1 bound to the LRH-1 promoter, both in cultured cells in vitro and during pancreatic development in vivo. Retroviral expression of PDX-1 in pancreatic cells induced the transcription of LRH-1, whereas reduced PDX-1 levels by RNA interference attenuated its expression. Consistent with direct regulation of LRH-1 expression by PDX-1, PDX-1(-/-) mice expressed smaller amounts of LRH-1 mRNA in the embryonic pancreas. Taken together, our data indicate that PDX-1 controls LRH-1 expression and identify LRH-1 as a novel downstream target in the PDX-1 regulatory cascade governing pancreatic development, differentiation, and function."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.19.6713-6724.2003"xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Auwerx J."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Swift G.H."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Schoonjans K."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Edlund H."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Fayard E."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Selander L."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/author | "Annicotte J.S."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/pages | "6713-6724"xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/title | "Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development."xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12972592 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12972592 |
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