| http://purl.uniprot.org/citations/12974773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/12974773 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DC) are vital in the defense against pathogens. To sense pathogens DC express pathogen recognition receptors such as toll-like receptors (TLR) and C-type lectins that recognize different fragments of pathogens, and subsequently activate or present pathogen fragments to T cells. It is now becoming evident that some pathogens subvert DC functions to escape immune surveillance. HIV-1 targets the DC-specific C-type lectin DC-SIGN to hijack DC for viral dissemination. HIV-1 binding to DC-SIGN protects HIV-1 from antigen processing and facilitates its transport to lymphoid tissues, where DC-SIGN promotes HIV-1 infection of T cells. Recent studies demonstrate that DC-SIGN is a more universal pathogen receptor that also recognizes Ebola, cytomegalovirus and mycobacteria. Mycobacterium tuberculosis targets DC-SIGN by a mechanism that is distinct from that of HIV-1, leading to inhibition of the immunostimulatory function of DC and pathogen survival. Thus, a better understanding of DC-SIGN-pathogen interactions and their effects on DC function is necessary to combat infections."xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1600-0463.2003.11107803.x"xsd:string |
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| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/author | "Geijtenbeek T.B."xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/author | "Geijtenbeek T.B."xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/author | "van Kooyk Y."xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/author | "van Kooyk Y."xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/name | "APMIS"xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/name | "APMIS"xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/pages | "698-714"xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/pages | "698-714"xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/title | "Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity."xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/title | "Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity."xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12974773 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12974773 |
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| http://purl.uniprot.org/uniprot/Q75008 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12974773 |