| http://purl.uniprot.org/citations/12975381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12975381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12975381 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular receptor for hepatitis B virus (HBV) has not yet been identified. A recent candidate is a homologue of squamous cell carcinoma antigen 1 (SCCA1), a serpin. This study confirms that transfection of SCCA1 into mammalian cells (both hepatocyte-derived and of non-hepatocyte origin) results in increased HBV binding. Furthermore, virus bound to transfected cells is protected significantly from degradation by trypsin (75% compared with 30% in untransfected cells). The possibility that HBV enters cells via the hepatic clearance system for serpin-enzyme complexes was investigated by analysis of the reactive site loop of SCCA1. Functional and deletion mutants of SCCA1 were constructed by site-directed mutagenesis and compared with the wild type construct. In no case was virus binding reduced by functional alterations or deletions within the reactive site loop. A possible role for the low density lipoprotein receptor-related protein (LRP) in binding virus was investigated. SCCA1 transfection of Huh7 cells was shown to result in up-regulation of LRP expression, reaching levels observed in total liver. However, the use of receptor-associated protein (RAP), a competitive ligand for LRP, suggests than LRP up-regulation is not responsible for enhanced virus binding to SCCA1-transfected cells."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302842200"xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302842200"xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/author | "Harrison T.J."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/author | "Harrison T.J."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/author | "Ong S."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/author | "Ong S."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/author | "Moore P.L."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/author | "Moore P.L."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/pages | "46709-46717"xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/pages | "46709-46717"xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/title | "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/title | "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12975381 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12975381 |
| http://purl.uniprot.org/citations/12975381 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12975381 |
| http://purl.uniprot.org/citations/12975381 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12975381 |
| http://purl.uniprot.org/citations/12975381 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12975381 |