| http://purl.uniprot.org/citations/1310501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1310501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1310501 | http://www.w3.org/2000/01/rdf-schema#comment | "Many multiresistance plasmids and transposons of gram-negative bacteria carry related DNA elements that appear to have evolved from a common ancestor by site-specific integration of discrete cassettes containing antibiotic resistance genes or sequences of unknown function. The site of integration is flanked by conserved segments coding for an integraselike protein and for sulfonamide resistance, respectively. These segments, together with the antibiotic resistance genes between them, have been termed integrons (H. W. Stokes and R. M. Hall, Mol. Microbiol. 3:1669-1683, 1989). We report here the characterization of an integron, In0, from Pseudomonas aeruginosa plasmid pVS1, which has an unoccupied integration site and hence may be an ancestor of more complex integrons. Codon usage of the integrase (int) and sulfonamide resistance (sul1) genes carried by this integron suggests a common origin. This contrasts with the codon usage of other antibiotic resistance genes that were presumably integrated later as cassettes during the evolution and spread of these DNA elements. We propose evolutionary schemes for (i) the genesis of the integrons by the site-specific integration of antibiotic resistance genes and (ii) the evolution of the integrons of multiresistance plasmids and transposons, in relation to the evolution of transposons related to Tn21."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.174.4.1248-1257.1992"xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.174.4.1248-1257.1992"xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/author | "Bissonnette L."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/author | "Bissonnette L."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/author | "Roy P.H."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/author | "Roy P.H."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/pages | "1248-1257"xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/pages | "1248-1257"xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/title | "Characterization of In0 of Pseudomonas aeruginosa plasmid pVS1, an ancestor of integrons of multiresistance plasmids and transposons of Gram-negative bacteria."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/title | "Characterization of In0 of Pseudomonas aeruginosa plasmid pVS1, an ancestor of integrons of multiresistance plasmids and transposons of Gram-negative bacteria."xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/1310501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1310501 |
| http://purl.uniprot.org/citations/1310501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1310501 |
| http://purl.uniprot.org/citations/1310501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1310501 |
| http://purl.uniprot.org/citations/1310501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1310501 |
| http://purl.uniprot.org/uniprot/P0AA24 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1310501 |
| http://purl.uniprot.org/uniprot/Q7BP38 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1310501 |