| http://purl.uniprot.org/citations/1311100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1311100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1311100 | http://www.w3.org/2000/01/rdf-schema#comment | "A full-length cDNA clone encoding a glutamate receptor was isolated from a human brain cDNA library, and the gene product was characterized after expression in Xenopus oocytes. Degenerate PCR primers to conserved regions of published rat brain glutamate receptor sequences amplified a 1-kilobase fragment from a human brain cDNA library. This fragment was used as a probe for subsequent hybridization screening. Two clones were isolated that, based on sequence information, code for different receptors: a 3-kilobase clone, HBGR1, contains a full-length glutamate receptor cDNA highly homologous to the rat brain clone GluR1, and a second clone, HBGR2, contains approximately two-thirds of the coding region of a receptor homologous to rat brain clone GluR2. Southern and PCR analysis of a somatic cell-hybrid panel mapped HBGR1 to human chromosome 5q31.3-33.3 and mapped HBGR2 to chromosome 4q25-34.3. Xenopus oocytes injected with in vitro-synthesized HBGR1 cRNA expressed currents activated by glutamate receptor agonists with the following specificity sequence: domoate greater than kainate much greater than quisqualate greater than or equal to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid greater than or equal to L-glutamate much greater than N-methyl-D-aspartate. The kainate-elicited currents were specifically blocked by 6-cyano-7-nitroquinoxaline-2,3-dione but were insensitive to 2-amino-5-phosphonovalerate and kynurenic acid. These results indicate that clone HBGR1 codes for a glutamate receptor of the kainate subtype cognate to members of the glutamate receptor family from rodent brain."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.4.1443"xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.4.1443"xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Evans G.A."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Evans G.A."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Montal M."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Montal M."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "McPherson J.P."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "McPherson J.P."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Ferrer-Montiel A.V."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Ferrer-Montiel A.V."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Schinder A.F."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/author | "Schinder A.F."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/pages | "1443-1447"xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/pages | "1443-1447"xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/title | "Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors."xsd:string |
| http://purl.uniprot.org/citations/1311100 | http://purl.uniprot.org/core/title | "Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors."xsd:string |