| http://purl.uniprot.org/citations/1314813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1314813 | http://www.w3.org/2000/01/rdf-schema#comment | "Administration of 5 mg of progesterone to late pregnant rats induced an increase in myometrial beta-adrenergic receptors density detected by 125I-cyanopindolol binding. This increase was significant after 24 h (1.4-fold; p less than 0.05) and reached 1.6-fold (p less than 0.05) after 36 h. The antiprogestin RU 486 or cycloheximide completely suppressed the effect of progesterone injection. Quantification of the beta 1- and beta 2-receptor subtypes revealed that progesterone selectively up-regulated the beta 2-subtype. The increase in beta 2-adrenoreceptors was preceded by an elevation of their mRNA (2.3 kilobases) levels as determined by Northern blot hybridization with a rat heart beta 2-adrenoreceptor cDNA probe. This increase was significant after 18 h of exposure to progesterone (2.1-fold; p less than 0.05) and reached a maximum after 24 h (3.4-fold; p less than 0.01). The rate of beta 2-adrenergic gene transcription evaluated by nuclear run-on transcription assays, increased by 2.5-fold in myometria exposed for 4 h to progesterone. This study indicates that progesterone regulates myometrial beta 2-adrenergic receptor expression by controlling the rate of transcription of the gene."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)42394-0"xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/author | "Legrand C."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/author | "Muzzin P."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/author | "Cohen-Tannoudji J."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/author | "Vivat V."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/author | "Revelli J.P."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/author | "Giacobino J.P."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/author | "Maltier J.P."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/pages | "7975-7978"xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/title | "Progesterone transcriptionally regulates the beta 2-adrenergic receptor gene in pregnant rat myometrium."xsd:string |
| http://purl.uniprot.org/citations/1314813 | http://purl.uniprot.org/core/volume | "267"xsd:string |
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