RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/1317796http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1317796http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1317796http://www.w3.org/2000/01/rdf-schema#comment"A potent inhibitor of protein kinase C (PKC), inhibitor protein-1 (KCIP-1), isolated from sheep brain has been shown to consist of eight isoforms by reverse-phase HPLC. Direct protein sequence analysis has revealed these to be the same as those of 14-3-3 protein, described as an activator of tyrosine and tryptophan hydroxylases involved in neurotransmitter biosynthesis. The N-termini of KCIP-1 isoforms were shown to be acetylated, and secondary structure predictions revealed a high degree of alpha-helix with an amphipathic nature. KCIP-1 showed no inhibitory activity towards protein kinase M (the catalytic fragment of PKC) and had no effect on the activities of three other protein kinases, cAMP-dependent protein kinase, Ca2+/calmodulin-dependent protein kinase II and casein kinase 2. Four forms of KCIP-1 were shown to be substrates for PKC in vitro, but none were phosphorylated by the other protein kinases mentioned above."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.org/dc/terms/identifier"doi:10.1111/j.1432-1033.1992.tb16946.x"xsd:string
http://purl.uniprot.org/citations/1317796http://purl.org/dc/terms/identifier"doi:10.1111/j.1432-1033.1992.tb16946.x"xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Aitken A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Aitken A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Amess B."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Amess B."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Harris A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Harris A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Patel Y."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Patel Y."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Sellers L.A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Sellers L.A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Toker A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/author"Toker A."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/date"1992"xsd:gYear
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/date"1992"xsd:gYear
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/name"Eur. J. Biochem."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/name"Eur. J. Biochem."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/pages"453-461"xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/pages"453-461"xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/title"Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3) from sheep brain. Amino acid sequence of phosphorylated forms."xsd:string
http://purl.uniprot.org/citations/1317796http://purl.uniprot.org/core/title"Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3) from sheep brain. Amino acid sequence of phosphorylated forms."xsd:string