| http://purl.uniprot.org/citations/1325785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1325785 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphoinositidase C activity was revealed in nuclei isolated from PC12 rat pheochromocytoma cells incubated with tritiated phosphatidylinositol, phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Phosphoinositide breakdown was found to be optimal at neutral pH and Ca++ concentrations ranging from endogenous levels to millimolar values. To characterize the enzymes involved, three monoclonal antibodies directed against the beta, gamma and delta phosphoinositidase C isoforms were employed. A combination of Western blot immunochemical analysis on cytoplasmic and nuclear fractions and of in situ immunocytochemistry on intact cells and isolated nuclei indicated that phosphoinositidase C gamma, though predominantly cytoplasmic, was present in both cell compartments. On the contrary, phosphoinositidase C beta was exclusively localized in the nucleus, whereas phosphoinositidase C delta was restricted to the cytoplasm. These data suggest that inositol lipid breakdown is controlled by different phosphoinositidase C isozymes in the various cell compartments, and support the notion that a separate phosphoinositide signalling system is located in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(05)81466-4"xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Milani D."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Manzoli F.A."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Marchisio M."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Neri L.M."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Mazzoni M."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Bertagnolo V."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Capitani S."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/author | "Carini C."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/pages | "114-120"xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/title | "Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells."xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/1325785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1325785 |
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| http://purl.uniprot.org/uniprot/#_A0A8I5ZP96-mappedCitation-1325785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1325785 |
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| http://purl.uniprot.org/uniprot/F1M084 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1325785 |