| http://purl.uniprot.org/citations/1328844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1328844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1328844 | http://www.w3.org/2000/01/rdf-schema#comment | "The canine RDC4 gene was used to isolate two distinct human serotonin receptor genes. The receptor encoded by clone RH-6 was the species homolog of RDC4 and was identical to a human serotonin 5-hydroxytryptamine1D (5-HT1D) receptor that was recently reported [Mol. Pharmacol. 40:143-148 (1991)]. The receptor encoded by RH-2 was a novel 5-HT receptor that was 61% identical to RH-6 and showed the greatest homology with the rat 5-HT1B receptor sequence (94%). The RH-2 gene contained an intronless, 1170-base pair, open reading frame that encoded a 390-amino acid protein that contained all of the hallmarks of a guanine nucleotide-binding protein-linked receptor. Heterologous expression of the RH-2 gene in Chinese hamster ovary cells led to the appearance of high affinity binding sites for 5-HT (Kd = 2.6 nM, Bmax = 2.9 pmol/mg of membrane protein), and the receptor expressed in Chinese hamster ovary cells was coupled to inhibition of adenylyl cyclase. Competition binding experiments using compounds that are selective for various 5-HT receptor subtypes showed the highest correlation with a 5-HT1D-like receptor (r = 0.89) and a low correlation with 5-HT1B-like receptors. Examples of the 5-HT1D-like pharmacology displayed by RH-2 include high affinity for the 5-HT1D-selective compound sumatriptan (Ki = 9.4 nM) and for the alpha 2-adrenergic receptor antagonist rauwolscine (Ki = 47 nM). Therefore, despite the close genetic relationship between RH-2 and the rat 5-HT1B receptor, our results indicate that the receptor encoded by RH-2 2 is best classified as a human 5-HT1D receptor subtype and defines a second member of the human 5-HT1D receptor family."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/author | "Bienkowski M.J."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/author | "Bienkowski M.J."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/author | "Veldman S.A."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/author | "Veldman S.A."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/name | "Mol. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/name | "Mol. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/pages | "439-444"xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/pages | "439-444"xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/title | "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/title | "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype."xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/1328844 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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| http://purl.uniprot.org/citations/1328844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1328844 |
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| http://purl.uniprot.org/citations/1328844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1328844 |
| http://purl.uniprot.org/uniprot/P28222 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1328844 |
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