| http://purl.uniprot.org/citations/1338904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1338904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1338904 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutations were detected. Twenty-one of them were point mutations; 16 nonsense and two missense mutations, and three occurred in introns at the splicing site. Twenty-two tumors had frameshift mutations due to deletion or insertion; nineteen of them were deletions of one to 31 bp and three were a 1-bp insertion. One tumor had a 1-bp deletion in an intron near the splicing site. Hence, 41 (95%) of 43 mutations resulted in truncation of the APC protein. Over 60% of the somatic mutations in the APC gene were clustered within a small region of exon 15, designated as MCR (mutation cluster region), which accounted for less than 10% of the coding region. Combining these data and the results of LOH, more than 80% of tumors (14 adenomas and 39 carcinomas) had at least one mutation in the APC gene, of which more than 60% (9 adenomas and 23 carcinomas) had two mutations. These results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority of colorectal tumors."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/1.4.229"xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/1.4.229"xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Aoki T."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Aoki T."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Mori T."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Mori T."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Miki Y."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Miki Y."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Ando H."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Ando H."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Ichii S."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Ichii S."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Miyoshi Y."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Miyoshi Y."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Nagase H."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Nagase H."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Nakatsuru S."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/author | "Nakatsuru S."xsd:string |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1338904 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |