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http://purl.uniprot.org/citations/1339311http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1339311http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1339311http://www.w3.org/2000/01/rdf-schema#comment"The tra-1 gene is the terminal control gene for somatic sex determination in the nematode Caenorhabditis elegans. Here we identify two tra-1 mRNAs: one is a 1.5 kb transcript that peaks in abundance in the second larval stage, and the other is a 5 kb transcript that is present at relatively constant abundance throughout development. Both RNAs occur at similar levels in both sexes, suggesting that regulation of tra-1 is posttranscriptional. Neither RNA is germline restricted. The two RNAs are colinear at their 5' ends: the shorter RNA encodes a protein with two zinc finger motifs, and the longer RNA encodes a protein with five zinc fingers. The identification of eight nonsense mutations confirms that these are authentic tra-1 RNAs and demonstrates that the longer one is essential for tra-1 activity. The transcription pattern reveals that alternative mRNA processing governs the number of zinc fingers in the resulting tra-1 protein. The tra-1 fingers are strikingly similar to those of three other proteins, the products of the human GLI and GLI3 and Drosophila cubitus interruptus Dominant (ciD) genes."xsd:string
http://purl.uniprot.org/citations/1339311http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(92)90099-x"xsd:string
http://purl.uniprot.org/citations/1339311http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(92)90099-x"xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/author"Hodgkin J."xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/author"Hodgkin J."xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/author"Zarkower D."xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/author"Zarkower D."xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/date"1992"xsd:gYear
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/date"1992"xsd:gYear
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/pages"237-249"xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/pages"237-249"xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/title"Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins."xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/title"Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins."xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/volume"70"xsd:string
http://purl.uniprot.org/citations/1339311http://purl.uniprot.org/core/volume"70"xsd:string
http://purl.uniprot.org/citations/1339311http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1339311
http://purl.uniprot.org/citations/1339311http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1339311
http://purl.uniprot.org/citations/1339311http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1339311
http://purl.uniprot.org/citations/1339311http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1339311
http://purl.uniprot.org/uniprot/P34708http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/1339311
http://purl.uniprot.org/uniprot/P34708#attribution-2EE5AB2754905C8CE00E134BFDB13D6Fhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/1339311