| http://purl.uniprot.org/citations/1345341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1345341 | http://www.w3.org/2000/01/rdf-schema#comment | "Bacterial lipopolysaccharide (LPS) produces rapid changes in macrophage protein synthesis and function. Phosphorylation of the 25 kDa mRNA cap-binding protein (eIF-4E) in model systems regulates the efficiency of protein synthesis. We report that both LPS and tumor necrosis factor-alpha (TNF-alpha) stimulate phosphorylation of eIF-4E and the p220 component of eIF-4F in bone marrow-derived macrophages. Moreover, anti-TNF-alpha antibodies inhibit LPS-stimulated phosphorylation of eIF-4E and p220 by 43% (+/- 6%) and 50% (+/-5%), respectively. Our results indicate that LPS stimulates eIF-4F phosphorylation by a TNF-alpha-dependent mechanism, and suggest that phosphorylation of eIF-4F might play a role in the post-transcriptional regulation of gene expression in macrophages exposed to LPS."xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/author | "Hagedorn C.H."xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/author | "Haas D.W."xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/author | "Shepherd V.L."xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/name | "Second Messengers Phosphoproteins"xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/pages | "163-171"xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/title | "Lipopolysaccharide stimulates phosphorylation of eukaryotic initiation factor-4F in macrophages and tumor necrosis factor participates in this event."xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/1345341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1345341 |
| http://purl.uniprot.org/citations/1345341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1345341 |
| http://purl.uniprot.org/uniprot/A0A0G2K5V6#attribution-FC975550F1559CE9EC3E8DADD9706898 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/G3V6H2#attribution-FC975550F1559CE9EC3E8DADD9706898 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/A6HGR6#attribution-FC975550F1559CE9EC3E8DADD9706898 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/A6HGR5#attribution-FC975550F1559CE9EC3E8DADD9706898 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/Q4FZS3#attribution-FC975550F1559CE9EC3E8DADD9706898 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/A6HGR7#attribution-FC975550F1559CE9EC3E8DADD9706898 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K5V6-mappedCitation-1345341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/#_G3V6H2-mappedCitation-1345341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/#_Q4FZS3-mappedCitation-1345341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/A0A0G2K5V6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/G3V6H2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1345341 |
| http://purl.uniprot.org/uniprot/Q4FZS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1345341 |