| http://purl.uniprot.org/citations/1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1353711 | http://www.w3.org/2000/01/rdf-schema#comment | "Hereditary tubulointerstitial nephritis is a prominent cause of renal failure in humans. A variety of animal models utilizing immunologically induced nephritis have been developed. The kdkd congenic variant of the CBA/Ca mouse has normal kidneys at birth but develops progressive, lethal autoimmune nephritis beginning at approximately Week 8. The destruction of renal tubular epithelium in mediated by a population of antigen-specific, H-2Kk-restricted, Lyt-2+, L3T4-T cells. The present experiments demonstrate that systemic treatment with anti-ICAM-1 monoclonal antibody reduces kidney disease in kdkd mice. Anti-ICAM-1 mab localizes to inflammatory sites in the kidney and effects a significant reduction in leukocyte infiltration. Concomitantly, urine protein levels of anti-ICAM-1-treated mice are significantly reduced. The use of anti-adhesion molecule monoclonal antibodies that alter leukocyte activity and/or trafficking may be useful therapies for certain autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.org/dc/terms/identifier | "doi:10.1016/0090-1229(92)90190-y"xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/author | "Pelletier J."xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/author | "Takei F."xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/author | "Van G."xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/author | "Merluzzi V.J."xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/author | "Harning R."xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/name | "Clin Immunol Immunopathol"xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/pages | "129-134"xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/title | "Monoclonal antibody to MALA-2 (ICAM-1) reduces acute autoimmune nephritis in kdkd mice."xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/1353711 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1353711 |
| http://purl.uniprot.org/citations/1353711 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1353711 |
| http://purl.uniprot.org/uniprot/#_P13597-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3THH5-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3U8M7-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q922B3-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3UDJ5-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3UE52-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3TB10-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3TB21-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3U7Q9-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |
| http://purl.uniprot.org/uniprot/#_Q3U7T2-mappedCitation-1353711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1353711 |