| http://purl.uniprot.org/citations/1360663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1360663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1360663 | http://www.w3.org/2000/01/rdf-schema#comment | "The PCR and conventional library screening were used to clone the brain-specific somatostatin receptor rSSTR-4 from a rat genomic library. The deduced amino acid sequence encodes a protein of 384 amino acids and displays structural and sequence homologies with members of the G protein-receptor superfamily. The amino acid sequence of rSSTR-4 is 60% and 48% identical to that of somatostatin receptors SSTR-1 and SSTR-2, respectively, two recently cloned subtypes. Competition curve analysis of the binding properties of the receptor transiently expressed in COS-1 cells revealed a higher apparent affinity for somatostatin 14 than for somatostatin 28. In contrast, the somatostatin analogs SMS 201-995, IM 4-28, and MK-678 failed to displace specific binding in transfected cells. These characteristics resemble the pharmacological binding properties of the previously described brain-specific somatostatin-receptor subtype. Examination of the tissue distribution of mRNA for rSSTR-4 revealed expression limited to various brain regions with highest levels in the cortex and hippocampus. Thus, based on the pharmacology and tissue localization of this receptor, we conclude that rSSTR-4 represents a brain-specific somatostatin receptor."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.23.11151"xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.23.11151"xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Bruno J.F."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Bruno J.F."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Berelowitz M."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/author | "Berelowitz M."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/pages | "11151-11155"xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/pages | "11151-11155"xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/title | "Molecular cloning and functional expression of a brain-specific somatostatin receptor."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/title | "Molecular cloning and functional expression of a brain-specific somatostatin receptor."xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1360663 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1360663 |
| http://purl.uniprot.org/citations/1360663 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1360663 |