| http://purl.uniprot.org/citations/13679383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/13679383 | http://www.w3.org/2000/01/rdf-schema#comment | "A humanized murine model was developed to study T cell tolerance to the hepatitis B surface antigen (HBsAg) that is present in sera of hepatitis B virus chronic carriers. The HBsAg/HLA-A2 double-transgenic mice express a chimeric HLA-A2 MHC class I molecule and a high amount of the HBsAg in the liver that is secreted and present in sera during the animal's lifetime. In these mice, injection of plasmid DNA encoding HBsAg induced a high frequency of CD8(+) T cells secreting IFN-gamma in the periphery, with in vitro cytolytic activity and specificity for two dominant HBs-specific HLA-A2-restricted epitopes. Nevertheless, the DNA-based immunization elicited neither T(h)1 nor T(h)2 CD4(+) T cell responses. Despite a high concentration of HBsAg in sera, these mice developed an immunocompetent CD8(+) T cell repertoire towards the viral self-antigen, whereas the CD4(+) T cell repertoire was tolerized. In the absence of a CD4(+) T cell response, the IFN-gamma-secreting CD8(+) T cells primed by DNA-based immunization were unable to exert their antiviral functions in vivo on liver cells expressing the transgene product. However, when pro-inflammatory stimuli were given before or after DNA-based immunization, the HBsAg was cleared from the serum. This effect was antibody dependent and associated with the detection of an HBs-specific T(h)1 CD4(+) T cell response in the periphery. This model provides evidence that HBsAg displayed a strong tolerogenic effect on the CD4(+) T cell compartment that is associated with a defect in CD8(+) T cell effector functions in vivo."xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxg117"xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/author | "Abastado J.P."xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/author | "Michel M.L."xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/author | "Loirat D."xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/author | "Mancini-Bourgine M."xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/pages | "1125-1136"xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/title | "HBsAg/HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection."xsd:string |
| http://purl.uniprot.org/citations/13679383 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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