| http://purl.uniprot.org/citations/1373499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1373499 | http://www.w3.org/2000/01/rdf-schema#comment | "The B-cell antigen receptors consist of membrane immunoglobulins (mIgs) noncovalently associated with two accessory proteins, MB-1 and Ig-beta. We used transfection into a nonlymphoid cell line to test whether MB-1 and Ig-beta were sufficient to promote cell surface expression of mIgM capable of signal transduction. Expression of MB-1 and Ig-beta, but not MB-1 alone, allowed high-level surface expression of mIgM in the AtT20 endocrine cell line, which presumably lacks other B-cell-specific components. The reconstituted antigen receptor was capable of mediating some of the signaling reactions characteristic of mIgM in B lymphocytes. Crosslinking mIgM on transfected AtT20 cells stimulated tyrosine phosphorylation of MB-1 and Ig-beta and also increased the amount of phosphatidylinositol 3-kinase activity that could be precipitated with anti-phosphotyrosine antibodies. When total cell lysates were analyzed by anti-phosphotyrosine immunoblotting, however, no induced phosphorylation of more abundant proteins was detected. Moreover, crosslinking of the receptor in AtT20 cells did not stimulate inositol phospholipid breakdown. Thus, the transfected B-cell antigen receptor could initiate some signal transduction events but AtT20 cells may lack components required for other signaling events associated with mIgM."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.89.8.3404"xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/author | "Kelly R.B."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/author | "Grosschedl R."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/author | "Gold M.R."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/author | "DeFranco A.L."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/author | "Travis A."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/author | "Matsuuchi L."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/pages | "3404-3408"xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/title | "The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line."xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/1373499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1373499 |
| http://purl.uniprot.org/citations/1373499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1373499 |
| http://purl.uniprot.org/uniprot/P08909#attribution-63DE1558C479230B39A07A18027D4B1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1373499 |
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| http://purl.uniprot.org/uniprot/P11911#attribution-63DE1558C479230B39A07A18027D4B1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1373499 |
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| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-1373499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1373499 |