http://purl.uniprot.org/citations/1373518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/1373518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/1373518 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocytes must proliferate and differentiate in response to low concentrations of a vast array of antigens. The requirements of broad specificity and sensitivity conflict because the former is met by low-affinity antigen receptors, which precludes achieving the latter with high-affinity receptors. Coligation of the membrane protein CD19 with the antigen receptor of B lymphocytes decreased the threshold for antigen receptor-dependent stimulation by two orders of magnitude. B lymphocytes proliferated when approximately 100 antigen receptors per cell, 0.03 percent of the total, were coligated with CD19. The B cell resolves its dilemma by having an accessory protein that enables activation when few antigen receptors are occupied."xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1373518"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1373518"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/author | "Carter R.H."xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/author | "Carter R.H."xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/author | "Fearon D.T."xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/author | "Fearon D.T."xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/pages | "105-107"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/pages | "105-107"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/title | "CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes."xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/title | "CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes."xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/volume | "256"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://purl.uniprot.org/core/volume | "256"xsd:string |
http://purl.uniprot.org/citations/1373518 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1373518 |
http://purl.uniprot.org/citations/1373518 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1373518 |
http://purl.uniprot.org/citations/1373518 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1373518 |
http://purl.uniprot.org/citations/1373518 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1373518 |
http://purl.uniprot.org/uniprot/P15391 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1373518 |
http://purl.uniprot.org/uniprot/P15391#attribution-399F3AD0309F2A0C1155B480E565CC46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1373518 |