| http://purl.uniprot.org/citations/1373874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1373874 | http://www.w3.org/2000/01/rdf-schema#comment | "Early pre-B cells derived from mouse lymphoid bone marrow cultures were expanded on a surrogate stromal cell line composed of NIH3T3 fibroblasts engineered to secrete interleukin 7 (IL-7). Three immortal, IL-7-dependent cell lines were generated and infected with recombinant retroviruses to determine the effects of the human follicular B-cell lymphoma gene, bcl-2, on immature stages of B-cell development. Cells expressing bcl-2 grew at rates similar to those of control (vector only) cells when plated on bone marrow stromal lines, but exhibited a c. two-fold net proliferative advantage when grown in liquid medium supplemented with IL-7 alone. Bcl-2 prevented apoptosis when the infected early pre-B-cell lines were deprived of IL-7 and other growth factors provided by stromal cells. Following factor deprivation, a subset of cells expressing bcl-2 survived indefinitely. Two such cultures spontaneously gave rise to factor-independent variants which grew slowly in unsupplemented liquid culture and formed agar colonies, yet still responded positively to IL-7 and kit ligand, and negatively to gamma-interferon. Bcl-2 thus provides a survival capacity and modest growth advantage to early pre-B cells, which may recapitulate its effects in human B cells bearing t(14;18) translocations and ultimately contribute to transformation."xsd:string |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/author | "Tsujimoto Y."xsd:string |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/author | "Endo K."xsd:string |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/author | "Borzillo G.V."xsd:string |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/pages | "869-876"xsd:string |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/title | "Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture."xsd:string |
| http://purl.uniprot.org/citations/1373874 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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