| http://purl.uniprot.org/citations/1375324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1375324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1375324 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD19 protein is expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells and has been implicated as a signal-transducing receptor in the control of proliferation and differentiation. Here we demonstrate complete correlation between the expression pattern of the CD19 gene and the B-cell-specific transcription factor BSAP in a large panel of B-lymphoid cell lines. The human CD19 gene has been cloned, and several BSAP-binding sites have been mapped by in vitro protein-DNA binding studies. In particular, a high-affinity BSAP-binding site instead of a TATA sequence is located in the -30 promoter region upstream of a cluster of heterogeneous transcription start sites. Moreover, this site is occupied by BSAP in vivo in a CD19-expressing B-cell line but not in plasma or HeLa cells. This high-affinity site has been conserved in the promoters of both human and mouse CD19 genes and was furthermore shown to confer B-cell specificity to a beta-globin reporter gene in transient transfection experiments. In addition, BSAP was found to be the only abundant DNA-binding activity of B-cell nuclear extracts that interacts with the CD19 promoter. Together, this evidence strongly implicates BSAP in the regulation of the CD19 gene."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.12.6.2662-2672.1992"xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.12.6.2662-2672.1992"xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Adams B."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Adams B."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Kozmik Z."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Kozmik Z."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Doerfler P."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/author | "Doerfler P."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/pages | "2662-2672"xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/pages | "2662-2672"xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/title | "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/title | "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/1375324 | http://purl.uniprot.org/core/volume | "12"xsd:string |