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http://purl.uniprot.org/citations/1376732http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1376732http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1376732http://www.w3.org/2000/01/rdf-schema#comment"A cDNA encoding a unique hyaluronan receptor has been molecularly cloned from a lambda GT11 3T3 cDNA expression library. Immunoblot analyses of cell lysates, using antibodies to peptides encoded in the cDNA, specifically react with a 58-kD protein. This protein is regulated by the mutant H-ras gene in cells containing a metallothionein promoter H-ras hybrid gene. Further, antibodies to peptide sequences encoded in the cDNA block the increase in locomotion resulting from induction of the mutant H-ras gene in this cell line. In a transblot assay, the bacterially expressed protein binds to biotinylated hyaluronan. Antibodies to peptides encoded in the cDNA react in immunoblot assays with the 58- and 52-kD proteins of a novel hyaluronan receptor complex previously implicated in cell locomotion. Furthermore, antibodies specific to the 58- and 52-kD proteins, which block ras-induced locomotion, also cross-react with the expressed, encoded protein. The gene product described here appears to be a new type of hyaluronan receptor that is involved in cell locomotion. It is named RHAMM, an acronym for receptor for hyaluronan-mediated motility."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.org/dc/terms/identifier"doi:10.1083/jcb.117.6.1343"xsd:string
http://purl.uniprot.org/citations/1376732http://purl.org/dc/terms/identifier"doi:10.1083/jcb.117.6.1343"xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hook M."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hook M."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Moore D."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Moore D."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Owens R."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Owens R."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hardwick C."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hardwick C."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Austen L."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Austen L."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Cripps V."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Cripps V."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hoare K."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hoare K."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hohn H.P."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Hohn H.P."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Nance D.M."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Nance D.M."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Turley E.A."xsd:string
http://purl.uniprot.org/citations/1376732http://purl.uniprot.org/core/author"Turley E.A."xsd:string