| http://purl.uniprot.org/citations/1377702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1377702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1377702 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor binding proteins (IGFBPs) are secreted by several cell types and can modify IGF actions. Mandin-Darby Bovine Kidney (MDBK) cells have been shown to secrete a 34,000 Da form of IGF binding protein whose N-terminal sequence is similar to a form of IGFBP purified from rat BRL-3A cells that has recently been named IGFBP-2. These studies report the complete amino acid sequence of bovine IGFBP-2 and compare its functional properties with human IGFBP-1. The protein is 81% identical to rat IGFBP-2. When compared with both rat IGFBP-2 and human IGFBP-1, the positions of all 18 cysteine residues are conserved. Similarly an RGD sequence is present near the carboxyl terminus in both proteins. IGFBP-2 has a higher affinity for IGF-II than for IGF-I and its affinity for both forms of IGF is greater than for human IGFBP-1. Like IGFBP-1 the protein can enhance the DNA synthesis response of porcine aortic smooth muscle cells to IGF-I; however, IGFBP-2 was much less potent. The maximum potentiation of the IGF-mediated mitogenic response that could be achieved was approximately 42% that of IGFBP-1. This potentiation is dependent upon a factor contained in platelet poor plasma and if this factor is omitted from the incubation medium, IGFBP-2 inhibits DNA synthesis. The purification of IGFBP-2 will allow more detailed comparisons to be made between it and other forms of IGFBPs in physiologic test systems."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.240480212"xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.240480212"xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Siegel N.R."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Siegel N.R."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Krivi G.G."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Krivi G.G."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Clemmons D.R."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Clemmons D.R."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Bourner M.J."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Bourner M.J."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Busby W.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "Busby W.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "McCusker R.H."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/author | "McCusker R.H."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/pages | "215-226"xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/pages | "215-226"xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/title | "Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): comparison of its structural and functional properties with IGFBP-1."xsd:string |
| http://purl.uniprot.org/citations/1377702 | http://purl.uniprot.org/core/title | "Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): comparison of its structural and functional properties with IGFBP-1."xsd:string |