| http://purl.uniprot.org/citations/1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1378867 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the Ia molecule in the early phase of B cell development remains controversial. In contrast to previous studies, we have detected minute amounts of Ia (I-A) molecule on early B lineage (B220+IgM-) cells from normal bone marrow, using ELISA. The presence of the I-A molecule even on pro-B cells was deduced from experiments in which a monoclonal anti-I-A antibody completely blocked the generation of pre-B cells from B progenitor (B220-) cells in stromal cell-dependent B cell culture. Inasmuch as this antibody did not inhibit the maturation of pre-B cells to IgM+ B cells in culture, the I-A molecule on early B lineage cells probably plays a role in their maturation. We also examined the role of the I-A molecule in early B cell development, using transgenic mice harboring the antisense DNA to I-A beta-chain gene. The amount of I-A molecule on splenic B cells from the young transgenic mice decreased in the presence of abundant amounts of the antisense RNA. B cell development was perturbed in spleen from the transgenic mice. Stromal cell-dependent B cell cultures from these mice clearly showed that the maturation of B lineage cells was delayed at a very early stage of development (B220-to B220+). We propose that the I-A molecule on early B lineage cells may play an essential role in their maturation."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/author | "Nishikawa S."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/author | "Miki N."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/author | "Imoto S."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/author | "Tokuhisa T."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/author | "Hatano M."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/author | "Nishikawa S.'"xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/author | "Wakita K."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/pages | "801-807"xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/title | "Role of I-A molecules in early stages of B cell maturation."xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/1378867 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1378867 |
| http://purl.uniprot.org/citations/1378867 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1378867 |
| http://purl.uniprot.org/uniprot/P14483#attribution-FF2D4864FBF095B45AD4800C42326741 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_P06343-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_P06345-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_P06346-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |
| http://purl.uniprot.org/uniprot/#_Q31135-mappedCitation-1378867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1378867 |