| http://purl.uniprot.org/citations/1380456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1380456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1380456 | http://www.w3.org/2000/01/rdf-schema#comment | "IRS-1 undergoes rapid tyrosine phosphorylation during insulin stimulation and forms a stable complex containing the 85 kDa subunit (p85) of the phosphatidylinositol (PtdIns) 3'-kinase, but p85 is not tyrosyl phosphorylated. IRS-1 contains nine tyrosine phosphorylation sites in YXXM (Tyr-Xxx-Xxx-Met) motifs. Formation of the IRS-1-PtdIns 3'-kinase complex in vitro is inhibited by synthetic peptides containing phosphorylated YXXM motifs, suggesting that the binding of PtdIns 3'-kinase to IRS-1 is mediated through the SH2 (src homology-2) domains of p85. Furthermore, overexpression of IRS-1 potentiates the activation of PtdIns 3-kinase in insulin-stimulated cells, and tyrosyl phosphorylated IRS-1 or peptides containing phosphorylated YXXM motifs activate PtdIns 3'-kinase in vitro. We conclude that the binding of tyrosyl phosphorylated IRS-1 to the SH2 domains of p85 is the critical step that activates PtdIns 3'-kinase during insulin stimulation."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1992.tb05426.x"xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1992.tb05426.x"xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Hu P."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Hu P."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "White M.F."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "White M.F."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Margolis B."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Margolis B."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Sun X.-J."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Sun X.-J."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Shoelson S.E."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Shoelson S.E."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Backer J.M."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Backer J.M."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Myers M.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Myers M.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Skolnik E.Y."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Skolnik E.Y."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Chin D.J."xsd:string |
| http://purl.uniprot.org/citations/1380456 | http://purl.uniprot.org/core/author | "Chin D.J."xsd:string |