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| http://purl.uniprot.org/citations/1383204 | http://www.w3.org/2000/01/rdf-schema#comment | "Nitric oxide (NO) is synthesized in mammals where it acts as a signal molecule for neurotransmission, vasorelaxation, and cytotoxicity. The NO synthases isolated from brain and cytokine-activated macrophages are FAD- and FMN-containing flavoproteins that display considerable sequence homology to NADPH-cytochrome P-450 reductase. However, the nature of their catalytic centers is unknown. We have found that both isoenzymes contain 2 mol of iron-protoporphyrin IX/mol of enzyme homodimer. The optical and EPR spectroscopic properties of the heme groups were found to be remarkably similar to those of high-spin cytochrome P-450. The heme iron in the resting NO synthase is ferric and five-coordinate with a cysteine thiolate as the proximal axial ligand. In addition, the EPR spectra of the resting NO synthases contained a free radical signal attributable to a bound flavin semiquinone that appeared to interact magnetically with the ferric heme iron. NO production was inhibited by carbon monoxide, implying a role for the heme groups in catalysis."xsd:string |
| http://purl.uniprot.org/citations/1383204 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)36718-3"xsd:string |
| http://purl.uniprot.org/citations/1383204 | http://purl.uniprot.org/core/author | "Stuehr D.J."xsd:string |
| http://purl.uniprot.org/citations/1383204 | http://purl.uniprot.org/core/author | "Ikeda-Saito M."xsd:string |
| http://purl.uniprot.org/citations/1383204 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1383204 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/1383204 | http://purl.uniprot.org/core/pages | "20547-20550"xsd:string |
| http://purl.uniprot.org/citations/1383204 | http://purl.uniprot.org/core/title | "Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical."xsd:string |
| http://purl.uniprot.org/citations/1383204 | http://purl.uniprot.org/core/volume | "267"xsd:string |
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