| http://purl.uniprot.org/citations/1383329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1383329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1383329 | http://www.w3.org/2000/01/rdf-schema#comment | "CD19 is a member of the Ig superfamily expressed on the surface of B lymphocytes that may be involved in the regulation of B cell function. Immunoprecipitation studies with B cell lines solubilized by digitonin have shown CD19 to be part of a multimolecular complex that includes CD21 (CR2) and other unidentified proteins. In this study, two of the CD19-associated proteins were identified as TAPA-1, which is expressed on most cell types, and Leu-13, which is expressed on subsets of lymphoid cells. TAPA-1 and Leu-13 are physically associated in many cell lineages. CD19 and CD21 mAb each specifically coprecipitated proteins of the same size as those precipitated by TAPA-1 and Leu-13 mAb from B cell lines and cDNA-transfected K562 cell lines. Western blot analysis with a TAPA-1 mAb verified the identity of TAPA-1 in CD19 and CD21 immunoprecipitated materials. In addition, when TAPA-1 or Leu-13 were crosslinked and patched on the cell surface, all of the CD19 comigrated with TAPA-1 and some of the CD19 comigrated with Leu-13. Furthermore, mAb binding to CD19, CD21, TAPA-1, and Leu-13 on B cell lines induced similar biologic responses, including the induction of homotypic adhesion, inhibition of proliferation, and an augmentation of the increase in intracellular [Ca2+] induced by suboptimal cross-linking of surface Ig on B cell lines. Together, these data suggest that TAPA-1 and Leu-13 are broadly expressed members of a signal transduction complex in which lineage-specific proteins, such as CD19 and CD21, provide cell-specific functions."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Tedder T.F."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Tedder T.F."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Levy S."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Levy S."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Bradbury L.E."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Bradbury L.E."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Evans R.L."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Evans R.L."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Kansas G.S."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/author | "Kansas G.S."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/pages | "2841-2850"xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/pages | "2841-2850"xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/title | "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/title | "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules."xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/1383329 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1383329 |
| http://purl.uniprot.org/citations/1383329 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1383329 |