| http://purl.uniprot.org/citations/1394122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1394122 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of a transforming growth factor alpha (TGF-alpha) transgene induced the development of liver tumors in 69 of 93 (74%) adult male mice. To identify factors associated with oncogenesis, liver tumors from transgenic animals were characterized at the molecular level. TGF-alpha RNA transcripts were elevated in 17 of 25 (68%) liver tumors, relative to adjacent nontumorous tissue. Expression of the endogenous c-myc and insulin-like growth factor II genes was enhanced in 7 of 19 (37%) and 12 of 16 (75%) tumors, respectively. In contrast, epidermal growth factor receptor RNA levels were unchanged or reduced in all liver tumors, and mutations were not detected in either the Ha-ras or Ki-ras genes. The occurrence of liver tumors in castrated TGF-alpha transgenic mice was reduced about 7-fold, while in ovariectomized transgenic animals the incidence was increased about 6-fold. The progeny of a cross between CD1-derived TGF-alpha transgenic (MT42) and C57BL/6 mice exhibited no reduction in tumor burden (83%); however, the incidence of tumor formation in MT42 x FVB/N offspring was substantially lower (19%). We conclude that in these transgenic mice TGF-alpha promotes tumor formation and appears to play a major role in tumor progression. Moreover, other factors that may collaborate in TGF-alpha-induced hepatocarcinogenesis include c-myc, insulin-like growth factor II, sex hormones, and the genetic background upon which the transgene operates."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/author | "Takagi H."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/author | "Merlino G."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/author | "Sharp R."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/author | "Fausto N."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/author | "Bradley M.O."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/author | "Goodrow T."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/author | "Hammermeister C."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/pages | "5171-5177"xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/title | "Molecular and genetic analysis of liver oncogenesis in transforming growth factor alpha transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/1394122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1394122 |
| http://purl.uniprot.org/citations/1394122 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1394122 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW49-mappedCitation-1394122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1394122 |
| http://purl.uniprot.org/uniprot/#_P48030-mappedCitation-1394122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1394122 |
| http://purl.uniprot.org/uniprot/#_Q545E4-mappedCitation-1394122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1394122 |
| http://purl.uniprot.org/uniprot/A0A0A6YW49 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1394122 |
| http://purl.uniprot.org/uniprot/P48030 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1394122 |
| http://purl.uniprot.org/uniprot/Q545E4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1394122 |