| http://purl.uniprot.org/citations/1397265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1397265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1397265 | http://www.w3.org/2000/01/rdf-schema#comment | "Four neurotoxic polypeptides (Tx2-1, Txt2-5, Tx2-6 and Tx2-9) were purified from the venom of the South American 'armed' spider Phoneutria nigriventer (Keys) by gel filtration and reverse phase FPLC and HPLC. These cysteine-rich polypeptides exhibited different levels of neurotoxicity in mice after intracerebroventricular injection. Tx2-1, Tx2-5 and Tx2-6 caused spastic paralysis and death, but the less toxic Tx2-9 produced only tail erection and scratching. The molecular weights of the polypeptides as determined by desorption mass spectroscoopy were 5838.8 for Tx2-1, 5116.6 (Tx2-5), 5291.3 (Tx2-6) and 3742.1 (Tx2-9). The complete amino acid sequences of the neurotoxins were determined by automated Edman degradation and by manual DABITC-PITC microsequence analysis of peptides obtained after digestions with various proteases. The amino acid sequences of Tx2-1 (53 residues), Tx2-5 (49 residues) and Tx2-6 (48 residues) were homologous, but had only limited similarities to the less toxic Tx2-9 (32 residues). All four polypeptides had varying sequence identities with other neurotoxins from different spider species and biologically active peptides from scorpions, a sea snail and seeds of Mirabilis jalapa."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.org/dc/terms/identifier | "doi:10.1016/0014-5793(92)81318-g"xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.org/dc/terms/identifier | "doi:10.1016/0014-5793(92)81318-g"xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Cordeiro M.N."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Cordeiro M.N."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Richardson M."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Richardson M."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Gilroy J."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Gilroy J."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Diniz C.R."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Diniz C.R."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Valentim A.D.C."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "Valentim A.D.C."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "von Eickstedt V.R.D."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/author | "von Eickstedt V.R.D."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/pages | "153-156"xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/pages | "153-156"xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/title | "The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian 'armed' spider Phoneutria nigriventer (Keys)."xsd:string |
| http://purl.uniprot.org/citations/1397265 | http://purl.uniprot.org/core/title | "The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian 'armed' spider Phoneutria nigriventer (Keys)."xsd:string |