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http://purl.uniprot.org/citations/1409593http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1409593http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1409593http://www.w3.org/2000/01/rdf-schema#comment"We have isolated a cDNA encoding a transcription factor that binds to the enhancer of major histocompatibility complex (MHC) class I genes. MHC-binding protein 2 (MBP-2) is a 275-kDa protein, containing two sets of widely separated zinc fingers and a stretch of highly acidic amino acids, a putative transactivation domain. The two zinc finger regions, when expressed individually as bacterial fusion proteins, bind with highest affinity to the MHC class I gene enhancer. Several proteins found in mammalian nuclear extracts bind the MHC class I enhancer in an electrophoresis mobility shift assay. Only one of these, a ubiquitously expressed factor, forming a slow-migrating retarded complex, can be supershifted by a MBP-2 antiserum. The same antiserum also precipitates a protein of greater than 250 kDa from COS cells transfected with a MBP-2 expression vector. Our data indicate that MBP-2 is a transcription factor involved in the regulation of MHC class I gene expression."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.org/dc/terms/identifier"doi:10.1073/pnas.89.19.8971"xsd:string
http://purl.uniprot.org/citations/1409593http://purl.org/dc/terms/identifier"doi:10.1073/pnas.89.19.8971"xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Bernards R."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Bernards R."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Isselbacher K.J."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Isselbacher K.J."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Lutz P."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Lutz P."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Van't Veer L.J."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/author"Van't Veer L.J."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/date"1992"xsd:gYear
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/date"1992"xsd:gYear
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/pages"8971-8975"xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/pages"8971-8975"xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/title"Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/title"Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes."xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/volume"89"xsd:string
http://purl.uniprot.org/citations/1409593http://purl.uniprot.org/core/volume"89"xsd:string
http://purl.uniprot.org/citations/1409593http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1409593
http://purl.uniprot.org/citations/1409593http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1409593