| http://purl.uniprot.org/citations/1415547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1415547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1415547 | http://www.w3.org/2000/01/rdf-schema#comment | "A Cl(-)-HCO3- exchanger in the brush-border membrane mediates active Cl-absorption and regulates intracellular pH in rabbit ileum. The molecular identity of the ileal Cl(-)-HCO3-exchanger has not been established. The best-characterized plasma membrane Cl(-)-HCO3-exchanger is erythroid band 3. Structurally related proteins in nonerythroid tissues comprise an anion exchanger (AE) family. We used the polymerase chain reaction to amplify and clone a cDNA encoding an ileal band 3-related protein (B3RP) from rabbit ileal enterocytes. The composite sequence is 3,909 bp and is predicted to encode a protein of 136 kDa. The deduced amino acid sequence is 95% identical to murine renal AE2, indicating that ileal B3RP is rabbit AE2. Antisera generated against a cytoplasmic fragment of ileal B3RP recognized a 160-to 170-kDa polypeptide in the brush-border membrane, but not the basolateral membrane, of ileal crypt and villus enterocytes. This correlates with previous studies indicating that a Cl(-)-HCO3-exchange is present in brush-border but not basolateral membrane vesicles from rabbit ileal enterocytes. We conclude that ileal B3RP is a product of the AE gene family, and is present in the brush-border of ileal enterocytes, where it may mediate Cl(-)-HCO3- exchange."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.1992.263.3.g345"xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.1992.263.3.g345"xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Igarashi P."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Igarashi P."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Chow A."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Chow A."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Aronson P.S."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Aronson P.S."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Dobbins J.W."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/author | "Dobbins J.W."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/pages | "G345-G352"xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/pages | "G345-G352"xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/title | "cDNA cloning and localization of a band 3-related protein from ileum."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/title | "cDNA cloning and localization of a band 3-related protein from ileum."xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/volume | "263"xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://purl.uniprot.org/core/volume | "263"xsd:string |
| http://purl.uniprot.org/citations/1415547 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1415547 |
| http://purl.uniprot.org/citations/1415547 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1415547 |