| http://purl.uniprot.org/citations/1428007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1428007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1428007 | http://www.w3.org/2000/01/rdf-schema#comment | "Fifty-four chimpanzee Patr-DRB and five human HLA-DRB second exons were cloned and sequenced from thirty-five chimpanzees and four human B-cell lines and compared with known Mhc-DRB sequences of these two species. Equivalents of the HLA-DRB1*02, -DRB1*03, -DRB1*07 allelic lineages and the HLA-DRB3, -DRB4, -DRB5, -DRB6, and -DRB7 loci were all found in the chimpanzee. In addition, two chimpanzee Patr-DRB lineages (Patr-DRBX and -DRBY) were found for which no human counterparts have been described. None of the Patr-DRB sequences is identical to known HLA-DRB sequences. The Patr-DRB1*0702 and HLA-DRB1*0701 alleles are the most similar sequences in a comparison between the two species and differ by only two nucleotides out of 246 sequenced. Equivalents of the HLA-DRB1*01, -DRB1*04, and -DRB1*09 alleles were not found in our sample of chimpanzees. A per locus comparison of the number of Patr-DRB alleles with the HLA-DRB alleles shows that the Patr-DRB3, -DRB4, -DRB5, and -DRB6 locus are, thus far, more polymorphic than their human homologs. The polymorphism of the Patr-DRB1 locus seems to be less extensive than that reported for the HLA-DRB1 locus. Nevertheless, the Patr-DRB1 locus seems to be the most polymorphic of the Patr-DRB loci. Phylogenetic analyses indicate that the HLA-DRB1*09 allele may have originated from a recombination between a Mhc-DRB5 allele and the DRB1 allele of a Mhc-DR7 haplotype. Although recombination seems to increase the diversity of the Patr-DRB alleles, its contribution to the generation of Patr-DRB variation is probably low. Hence, most Patr-DRB diversity presumably accumulated via recurrent point mutations. Finally, two distinct Patr-DRB haplotypes are deduced, one of which (the chimpanzee equivalent of the HLA-DR7 haplotype) is probably older than 6-8 million years."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.org/dc/terms/identifier | "doi:10.1007/BF00223539"xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00223539"xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Bontrop R.E."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Bontrop R.E."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Jonker M."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Jonker M."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Otting N."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Otting N."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Kenter M."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Kenter M."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Schipper R."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Schipper R."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Anholts J."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/author | "Anholts J."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/pages | "1-11"xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/pages | "1-11"xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/title | "Mhc-DRB diversity of the chimpanzee (Pan troglodytes)."xsd:string |
| http://purl.uniprot.org/citations/1428007 | http://purl.uniprot.org/core/title | "Mhc-DRB diversity of the chimpanzee (Pan troglodytes)."xsd:string |