| http://purl.uniprot.org/citations/1431100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1431100 | http://www.w3.org/2000/01/rdf-schema#comment | "We have examined the functional importance of binding sites for C/EBP family members (E sites), in two Ig VH promoters: VH1, a member of the S107 family, and BCL1, a member of the J558 family. Mutation of the E site in the VH1 promoter diminishes transcription in vivo to 59% of wild-type and transcription from the BCL1 promoter in vitro is inhibited to an average of 39% of wild-type by competition with E site oligonucleotides. Purified E site binding proteins from plasmacytoma cells stimulated BCL1 transcription in vitro 2.3-fold. Although five C/EBP family proteins are known which bind the E site, antibody ablation of DNA:protein complexes resolved by electrophoretic mobility shift assays showed that Ig/EBP-1 is the only E site binding protein detectable in early B cell lines; more mature B cells contain Ig/EBP-1 and NF-IL6. We also show by antibody-depletion that Ig/EBP-1 activates the BCL1 promoter in vitro."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/author | "Cooper C."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/author | "Tucker P."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/author | "Calame K."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/author | "Roman C."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/author | "Avitahl N."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/pages | "3225-3231"xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/title | "The C/EBP family of transcriptional activators is functionally important for Ig VH promoter activity in vivo and in vitro."xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/1431100 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1431100 |
| http://purl.uniprot.org/citations/1431100 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1431100 |
| http://purl.uniprot.org/uniprot/P53568#attribution-625DBC4BB3EB9D2CA6203C2B83EF258B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1431100 |
| http://purl.uniprot.org/uniprot/P53568#attribution-F432049048BB595342AA3F56F4A2C4CB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1431100 |
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| http://purl.uniprot.org/uniprot/P53568 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1431100 |
| http://purl.uniprot.org/uniprot/Q54AJ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1431100 |